abstract：BACKGROUND:Variation of lung function is considered to be a hallmark of asthma. Although guidelines recommend measuring it as a diagnostic tool for asthma, the usefulness of this approach has not been studied in children. AIM:To assess the usefulness of home spirometry in children with nonspecific lower respiratory tr...

journal_title：Pediatric pulmonology

authors： Brouwer AF,Visser CA,Duiverman EJ,Roorda RJ,Brand PL

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Most methods used for the assessment of severe steatorrhea in cystic fibrosis (CF) are sensitive. In fact, the tests show their usefulness in a borderline zone of the results. Yet, the existing data related to acid steatocrit (AS) are still contradictory. Therefore, in the present study we have aimed to asse...

journal_title：Pediatric pulmonology

authors： Walkowiak J,Lisowska A,Blask-Osipa A,Drzymała-Czyz S,Sobkowiak P,Cichy W,Breborowicz A,Herzig KH,Radzikowski A

更新日期：2010-03-01 00:00:00

abstract：:Dysfunctional swallowing is an uncommon, but important cause of bronchiectasis. We describe a child with a brainstem tumor, who developed bronchiectasis caused by chronic aspiration secondary to a dysfunctional swallow. The case highlights the importance of thorough and repeated evaluation before a diagnosis of idiopa...

journal_title：Pediatric pulmonology

authors： Bossley CJ,Hogg C,Stoneham S,Jacques TS,Bush A

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To describe the clinical course and treatment of an infant with acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation. DESIGN:Case report. SETTING:A tertiary care University-affiliated hospital. PATIENT, INTERVENTION, AND RESULTS:An 8-month-old girl de...

journal_title：Pediatric pulmonology

authors： Atwa K,Abuhasna S,Shihab Z,Hashaykeh N,Hasan R

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Treatment regimens for patients with cystic fibrosis (CF) are time-consuming and complex, resulting in consistently low adherence rates. To date, few studies have evaluated innovative technologies to improve adherence in this population. Current infection control guidelines for patients with CF seek to minim...

journal_title：Pediatric pulmonology

authors： Marciel KK,Saiman L,Quittell LM,Dawkins K,Quittner AL

更新日期：2010-02-01 00:00:00

abstract：:Better growth and nutritional status is strongly associated with better pulmonary function and survival in children with CF. Behavioral intervention is an efficacious treatment approach for improving calorie intake and weight gain in children with CF; and recently has been shown to facilitate maintenance of daily ener...

journal_title：Pediatric pulmonology

authors： Opipari-Arrigan L,Powers SW,Quittner AL,Stark LJ

更新日期：2010-01-01 00:00:00

abstract：:Multiple breath inert gas washout (MBW) is gaining popularity for measurements of resting lung volume and ventilation inhomogeneity. Test reproducibility is an important determinant of the clinical applicability of diagnostic tests. The between-test reproducibility of variables derived from MBW tests in newborn infant...

journal_title：Pediatric pulmonology

authors： Sinhal S,Galati J,Baldwin DN,Stocks J,Pillow JJ

更新日期：2010-01-01 00:00:00

abstract：:There is increasing interest in using the Multiple Breath Washout technique and the lung clearance index (LCI) for detecting early pulmonary changes, for example, in cystic fibrosis lung disease. However, there are still limited data regarding equipment specific reference ranges, repeatability and reproducibility. The...

journal_title：Pediatric pulmonology

authors： Fuchs SI,Eder J,Ellemunter H,Gappa M

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:To determine B-type natriuretic peptide (BNP) levels in infants and children with acute lung injury (ALI), and to investigate associations between BNP levels and clinical outcome. DESIGN:Prospective observational study. SUBJECTS:After informed consent, plasma was collected from 48 pediatric patients on day...

journal_title：Pediatric pulmonology

authors： Reel B,Oishi PE,Hsu JH,Gildengorin G,Matthay MA,Fineman JR,Flori H

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:High incidence of genetic alterations at the microsatellite (MS) DNA level has been reported in asthmatic adults. WORKING HYPOTHESIS:The aim of this study was to investigate whether microsatellite instability (MSI) and loss of heterozygosity (LOH) were detectable phenomena in children with asthma. METHODOL...

journal_title：Pediatric pulmonology

authors： Thomou C,Paraskakis E,Neofytou E,Kalmanti M,Siafakas NM,Tzortzaki EG

更新日期：2009-10-01 00:00:00

abstract：:Pertussis carries a high risk of mortality in very young infants. The mechanism of refractory cardio-respiratory failure is complex and not clearly delineated. We aimed to examine the clinico-pathological features and suggest how they may be related to outcome, by multi-center review of clinical records and post-morte...

journal_title：Pediatric pulmonology

authors： Sawal M,Cohen M,Irazuzta JE,Kumar R,Kirton C,Brundler MA,Evans CA,Wilson JA,Raffeeq P,Azaz A,Rotta AT,Vora A,Vohra A,Abboud P,Mirkin LD,Cooper M,Dishop MK,Graf JM,Petros A,Klonin H

更新日期：2009-10-01 00:00:00

abstract：:Several enzyme-linked immunosorbent assays (ELISAs) based on mycobacterial antigens have been tried for the rapid diagnosis of tuberculosis (TB). In this study, the value of the 16 and 38-kDa mycobacterial antigens in the diagnosis of TB was investigated in pediatric patients in Izmir, Turkey in whom they were found u...

journal_title：Pediatric pulmonology

authors： Senol G,Ecevit C,Oztürk A

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The pH of exhaled breath condensate (EBC) of adolescent athletes engaged in vigorous physical activity is low compared to healthy controls; however, the ionic determinants of EBC pH and the acute effects of exercise on those determinants have not been definitively established. OBJECTIVES:This study had two ...

journal_title：Pediatric pulmonology

authors： Greenwald R,Ferdinands JM,Teague WG

更新日期：2009-08-01 00:00:00

abstract：:We reviewed the literature on the effects of high flow nasal cannula (HFNC) and heated, humidified, high-flow, nasal cannula (HHHFNC) treatment in preterm infants. We found nine studies, but only two were randomized controlled trials. These studies show that: HFNC application is associated to the delivery of continuou...

journal_title：Pediatric pulmonology

authors： Dani C,Pratesi S,Migliori C,Bertini G

更新日期：2009-07-01 00:00:00

abstract：:Lung transplantation in childhood is a highly specialized clinical practice confined to a few centers around the world. Organ availability remains an important limiting factor in extending the application of this procedure to more infants, children and adolescents. The lungs are the organ most vulnerable to injury, in...

journal_title：Pediatric pulmonology

authors： Mallory GB Jr,Schecter MG,Elidemir O

更新日期：2009-06-01 00:00:00

abstract：:We report a case of fungal pleural effusion secondary to presumed valproate induced pancreatitis with pseudocyst and stricture formation. A child with dyskinetic cerebral palsy who had been on sodium valproate for several years was transferred for drainage of a left sided pleural effusion. Pleural fluid culture consis...

journal_title：Pediatric pulmonology

authors： Gupta A,Marrs T,Urquhart D,Clarke S,Rosenthal M,Bush A

更新日期：2009-06-01 00:00:00

abstract：:Acute mycoplasma pneumonia may be accompanied by wheeze in some children considered not to have asthma. The aim of the present study was to evaluate cytokine secretion in children with acute mycoplasma pneumonia and wheeze. We studied 58 patients with mycoplasma pneumonia (12 with wheeze, Group 1; 46 without wheeze, G...

journal_title：Pediatric pulmonology

authors： Choi IS,Byeon JH,Yoo Y,Lee KC,Choung JT

更新日期：2009-05-01 00:00:00

abstract：:The value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake (VO2) during early recovery following maximal cardiopulmonary exercise testing (CPXT) in relatio...

journal_title：Pediatric pulmonology

authors： Stevens D,Oades PJ,Armstrong N,Williams CA

更新日期：2009-05-01 00:00:00

abstract：:The consequences of poor quality and/or inadequate sleep in children and adolescents have become a major public health concern, and one in which pediatric health care professionals have become increasingly involved. In particular, insufficient and/or fragmented sleep resulting from primary sleep disorders such as obst...

journal_title：Pediatric pulmonology

authors： Owens JA

更新日期：2009-05-01 00:00:00

abstract：:Antimicrobial proteins are important in lung defense and are potential therapeutic agents in chronic airways infection such as seen in cystic fibrosis (CF). In preparation for future clinical studies, we sought (1) to determine levels of three antimicrobial proteins [lactoferrin, lysozyme, and secretory leukoprotease ...

journal_title：Pediatric pulmonology

authors： Sagel SD,Sontag MK,Accurso FJ

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Peripheral muscle dysfunction is increasingly recognized as complicating respiratory disease, but this is difficult to measure non-invasively. RESEARCH QUESTION:Can skeletal muscle function and efficiency be measured during exercise non-invasively using respiratory mass spectrometry (RMS); and is the know...

journal_title：Pediatric pulmonology

authors： Rosenthal M,Narang I,Edwards L,Bush A

更新日期：2009-03-01 00:00:00

abstract：:In adults abdominal obesity is related to lung dysfunction and waist circumference (WC) predicts pulmonary function. It is not known how WC affects pulmonary function in children. A cross-sectional study of 718 children 6-17 years of age was conducted in a rural community to determine the predictability of WC for pulm...

journal_title：Pediatric pulmonology

authors： Chen Y,Rennie D,Cormier Y,Dosman JA

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To carry out a cost-effectiveness analysis of omitting chest radiography in the diagnosis of infant bronchiolitis. HYPOTHESIS:Omitting chest radiographs in the diagnosis of typical bronchiolitis was expected to reduce costs without adversely affecting the detection rate of alternate diseases. STUDY DESIGN:A...

journal_title：Pediatric pulmonology

authors： Yong JH,Schuh S,Rashidi R,Vanderby S,Lau R,Laporte A,Nauenberg E,Ungar WJ

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To develop and validate a questionnaire to assess asthma control in children (CAN). DESIGN:Two versions of the CAN (for carers and children) were developed. Both versions were validated in an observational, prospective, multicenter study performed in 38 hospital outpatient clinics throughout Spain. Four hund...

journal_title：Pediatric pulmonology

authors： Pérez-Yarza EG,Badía X,Badiola C,Cobos N,Garde J,Ibero M,Villa JR,CAN Investigator Group.

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Simulated exhaled nitric oxide (eNO) depends on ventilatory settings used in different experimental conditions. OBJECTIVES:To normalize the simulated minute exhaled nitric oxide according to different ventilatory settings. WORKING HYPOTHESIS:Different ventilatory settings influence the concentrations of ex...

journal_title：Pediatric pulmonology

authors： Figueras-Aloy J,Berrueco R,Salvia-Roiges MD,Rodríguez-Miguélez JM,Miracle-Echegoyen X,Botet-Mussons F,Mur-Sierra A,Vall O,Carbonell-Estrany X

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:Nitric oxide (NO) produced in the lung is an important mediator of normal lung development, vascular smooth muscle relaxation, and ventilation perfusion matching. NO is synthesized from arginine by the action of NO-synthase (NOS). Asymmetric dimethylarginine (ADMA), an endogenous derivate of arginine, inhibit...

journal_title：Pediatric pulmonology

authors： Richir MC,van Leeuwen PA,van den Berg A,Wessels R,Twisk JW,Rauwerda JA,Teerlink T,de Vries TP,van Elburg RM

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:To define the benefits of a flexible bronchoscopy (FB) service in a Paediatric Intensive Care Unit (PICU). DESIGN:Review of the first 200 FBs undertaken in a large PICU. SETTING:Large cardiac and medical PICU in the United Kingdom, also providing extra-corporeal life support. PATIENTS:129 patients (78 male...

journal_title：Pediatric pulmonology

authors： Davidson MG,Coutts J,Bell G

更新日期：2008-12-01 00:00:00

abstract：:Sleep disordered breathing (SDB) represents a spectrum of breathing disorders, ranging from snoring to obstructive sleep apnea syndrome (OSAS), that disrupt nocturnal respiration and sleep architecture. OSAS is a common disorder in children, with a prevalence of 2-3%. It is associated with neurobehavioral, cognitive, ...

journal_title：Pediatric pulmonology

authors： Goldbart AD,Tal A

更新日期：2008-12-01 00:00:00

abstract：:Two patients with intractable chronic cough were found to have tonsillar tissue impinging on their epiglottis. In both case, tonsillectomy was curative. The observations in these patients are consistent with a previous report indicating chronic cough from the uvula in contact with the epiglottis with cough cessation f...

journal_title：Pediatric pulmonology

authors： Gurgel RK,Brookes JT,Weinberger MM,Smith RJ

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Inhaled hypertonic saline (HS) improves lung function and decreases pulmonary exacerbations in older patients with cystic fibrosis (CF). Initiating therapies in young patients has potential to preserve lung function. Before conducting a therapeutic trial of HS in this population, its safety must be evaluated...

journal_title：Pediatric pulmonology

authors： Dellon EP,Donaldson SH,Johnson R,Davis SD

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND/AIM:There has been recent interest in dry powder inhaled mannitol as a therapeutic agent in patients with cystic fibrosis (CF). It is has been shown to increase mucociliary clearance (MCC) by rehydrating the airway. To date there have been no studies exclusively in children with CF examining the effect of dr...

journal_title：Pediatric pulmonology

authors： Minasian C,Wallis C,Metcalfe C,Bush A

更新日期：2008-11-01 00:00:00

abstract：:We present a 9-month-old infant with persistent cough refractory to conventional asthma therapy. An extensive evaluation eventually revealed a Chiari I malformation with syringohydromyelia. His cough resolved one month after surgical decompression, suggesting that brainstem compression from the Chiari malformation dir...

journal_title：Pediatric pulmonology

authors： Amos LB,Quintero DR

更新日期：2008-10-01 00:00:00

abstract：:Pulmonary sequestration is a rare anomaly and is conventionally treated with surgical excision. This report describes the successful occlusion of a large aberrant artery to an intralobar pulmonary sequestration using an Amplatzer Vascular Plug. ...

journal_title：Pediatric pulmonology

authors： Hwang HK,Tsai YS,Lin SM,Chen MR

更新日期：2008-09-01 00:00:00

abstract：:Glucocorticoids are given antenatally to promote pulmonary epithelial maturation and prevent respiratory distress syndrome in premature newborns. In contrast to airway changes, effects on vessels are less documented. We hypothesized that antenatal betamethasone (BM) administration promotes vascular development. Does r...

journal_title：Pediatric pulmonology

authors： Roubliova XI,Lewi PJ,Vaast P,Jani JC,Verbeken EK,Tibboel D,Deprest JA

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of position on the strength of the Hering-Breuer reflex in prematurely born infants and determine whether any differences seen were related to differences in lung or tidal volume between positions. WORKING HYPOTHESIS:Position related differences in the strength of the Hering-Breuer...

journal_title：Pediatric pulmonology

authors： Landolfo F,Saiki T,Peacock J,Hannam S,Rafferty GF,Greenough A

更新日期：2008-08-01 00:00:00

abstract：:Fetal lung hypoplasia is a common finding in several fetal conditions such as congenital diaphragmatic hernia (CDH). Interestingly, previous studies have demonstrated that hypoplastic lungs have the ability to recover to normal size, when relieved from mechanical factors. However, the underlying mechanisms remain larg...

journal_title：Pediatric pulmonology

authors： Nogueira-Silva C,Moura RS,Esteves N,Gonzaga S,Correia-Pinto J

更新日期：2008-07-01 00:00:00

abstract：:Maternal retinoid administration has beneficial effects on lung development in the nitrofen rodent toxic model of congenital diaphragmatic hernia (DH). We wanted to investigate the effects in a surgical model, where the retinoid signaling pathway is not primarily disrupted by the toxic agent. We created DH in fetal ra...

journal_title：Pediatric pulmonology

authors： Gallot D,Coste K,Jani J,Roubliova X,Marceau G,Velemir L,Verheyen A,Lemery D,Sapin V,Deprest J

更新日期：2008-06-01 00:00:00

abstract：:Allergic bronchopulmonary aspergillosis (ABPA) is a complication commonly encountered in patients with CF that produces significant respiratory morbidity. Chronic airway colonization with Aspergillus induces strong inflammatory responses with high IgE levels. Current guidelines for therapy include prolonged courses of...

journal_title：Pediatric pulmonology

authors： Zirbes JM,Milla CE

更新日期：2008-06-01 00:00:00

abstract：:The goal of this research was to begin the process of evaluating acceptability of infection control (IC) recommendations to CF patients and their families, determine whether compliance with IC guidelines differs from compliance with traditional CF medical treatment with respect to the variables predictive of complianc...

journal_title：Pediatric pulmonology

authors： Masterson T,Wildman BG,Newberry B,Omlor G,Bryson E,Kukay A

更新日期：2008-05-01 00:00:00

abstract：:Airway obstruction in children is a rare, but difficult clinical problem, with no clear agreement on optimal therapeutic approach. Stenting of the airway has been used successfully in adults, and is an attractive alternative in children. Fundamental differences of pediatric compared to adult use include the benign nat...

journal_title：Pediatric pulmonology

authors： Nicolai T

更新日期：2008-04-01 00:00:00